FOR U.S. RESIDENTS ONLY AGE 18 AND OVER

MANAGING TYPE 2 DIABETES

Diabetes monitor icon

Type 2 diabetes is
the most common form
of diabetes

Physical activity heart rate pulse icon

Physical activity along with diet can help manage your blood sugar

Online tools and apps icon

Online tools and apps
can help you manage
a healthier lifestyle

ABOUT TYPE 2 DIABETES

If you have type 2 diabetes, you're not alone. Did you know that type 2 diabetes is the most common form of diabetes? In fact, 90-95% of all diabetes cases in America are type 2.

You probably already know that when you have type 2 diabetes, your pancreas doesn't produce enough insulin, a hormone that helps lower glucose, and your body may not use the insulin it produces effectively.

Without the right amount of insulin, glucose can build up in your bloodstream. Because high blood glucose can seriously affect your health, monitoring and managing your blood glucose numbers is an important part of your treatment plan.

Signs of high blood sugar levels:

    Symptoms of type 2 diabetes include the following:
  • Excessive thirst and frequent bathroom trips
  • Extreme hunger
  • Fatigue, or feeling of being "run down"
  • Tingling or burning pain in the feet, legs, hands, or other body parts
  • Unexplained weight loss
  • Frequent infections
  • Slow healing of cuts and bruises
  • Blurred vision

While the exact causes of type 2 diabetes aren't completely understood, we do know that hereditary factors can predispose you to the condition. Environmental or lifestyle factors can also be triggers for people with a genetic predisposition to the condition.

Risk factors include:

  • Age (as you get older, your risk for type 2 diabetes goes up)
  • Race (African Americans, Mexican Americans, American Indians, Native Hawaiians, Pacific Islanders, and Asian Americans have a higher risk for type 2 diabetes)
  • Family history
  • Being overweight
  • High blood glucose (sugar)
  • For women, a history of diabetes during pregnancy (gestational diabetes)
  • High blood pressure
  • Unhealthy cholesterol levels
  • Physical inactivity
  • Smoking
  • Unhealthy eating
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HEALTHY LIVING

Having type 2 diabetes doesn't mean you can't live life to the fullest. You can still do all the things you love – like watching sports with your friends, going to BBQs, and cooking your favorite dishes. You just have to make small lifestyle changes so you can better manage your blood sugar level.

If your doctor says it's okay for you to increase your physical activity, choose something you like to do. Maybe go for a hike, swim a few laps, play a round of golf, or ride a bike for 30 minutes. Workouts won't seem like work at all when you're having fun.

Staying active is just one part of a good treatment plan. You also have to eat well and take your medication as your doctor prescribes. Together, these things can help lower your blood sugar numbers. Managing your blood sugar is important as it may mean a lower A1C.

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What are JENTADUETO and JENTADUETO XR?

JENTADUETO and JENTADUETO XR are prescription medicines that contains 2 diabetes medicines, linagliptin and metformin. JENTADUETO and JENTADUETO XR can be used along with diet and exercise to lower blood sugar in adults with type 2 diabetes when treatment with both linagliptin and metformin is appropriate.

JENTADUETO and JENTADUETO XR are not for people with type 1 diabetes or for people with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had inflammation of the pancreas (pancreatitis) in the past, it is not known if you have a higher chance of getting pancreatitis while you take JENTADUETO or JENTADUETO XR.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about JENTADUETO or JENTADUETO XR?

JENTADUETO and JENTADUETO XR can cause serious side effects, including Lactic Acidosis (a build-up of lactic acid in the blood). Metformin, one of the medicines in JENTADUETO and JENTADUETO XR, can cause lactic acidosis, a rare but serious condition that can cause death. Lactic acidosis is a medical emergency and must be treated in a hospital.

Call your doctor right away if you get any of the following symptoms, which could be signs of lactic acidosis: feel cold in your hands or feet, feel dizzy or lightheaded, have a slow or irregular heartbeat, feel very weak or tired, have unusual muscle pain, have trouble breathing, feel sleepy or drowsy, have stomach pains, nausea, or vomiting.

You have a higher chance of getting lactic acidosis with JENTADUETO or JENTADUETO XR if you have severe kidney problems or your kidneys are affected by certain x-ray tests that use injectable dye, liver problems, drink alcohol very often, or drink a lot of alcohol in short term (“binge” drinking), get dehydrated (lose a large amount of body fluids), have surgery, have a heart attack, severe infection, or stroke.

Inflammation of the pancreas (pancreatitis) is another serious side effect that can happen to people taking JENTADUETO or JENTADUETO XR. Pancreatitis may be severe and lead to death. Before you start taking JENTADUETO or JENTADUETO XR tell your doctor if you have ever had pancreatitis, gallstones, a history of alcoholism, or high triglyceride levels.

Stop taking JENTADUETO or JENTADUETO XR and call your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis.

Heart failure. Heart failure means your heart does not pump blood well enough. Before you start taking JENTADUETO or JENTADUETO XR, tell your doctor if you have ever had heart failure or have problems with your kidneys. Contact your doctor right away if you have any of the following symptoms: increasing shortness of breath or trouble breathing, especially when you lie down; swelling or fluid retention, especially in the feet, ankles, or legs; an unusually fast increase in weight or unusual tiredness. These may be symptoms of heart failure.

Who should not take JENTADUETO or JENTADUETO XR?

Do not take JENTADUETO or JENTADUETO XR if you:

What should I tell my doctor before using JENTADUETO or JENTADUETO XR?

Tell your doctor about all of your medical conditions, including if you:

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. JENTADUETO or JENTADUETO XR may affect the way other medicines work, and other medicines may affect how JENTADUETO or JENTADUETO XR works.

Especially tell your doctor if you take:

*These trademarks are owned by third parties not affiliated with JENTADUETO or JENTADUETO XR.

What are the possible side effects of JENTADUETO and JENTADUETO XR?

JENTADUETO and JENTADUETO XR may cause serious side effects, including:

The most common side effects of JENTADUETO and JENTADUETO XR include stuffy or runny nose, sore throat, and diarrhea.

These are not all the possible side effects of JENTADUETO and JENTADUETO XR. For more information, ask your doctor or pharmacist.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑10881‑800‑FDA‑1088.

CL-JD-100001 8.21.17

Please see Prescribing Information, including Boxed Warning about lactic acidosis, and Medication Guide for JENTADUETO.
Please see Prescribing Information, including Boxed Warning about lactic acidosis, and Medication Guide for JENTADUETO XR.

What are JENTADUETO and JENTADUETO XR?

JENTADUETO and JENTADUETO XR are prescription medicines that contains 2 diabetes medicines, linagliptin and metformin. JENTADUETO and JENTADUETO XR can be used along with diet and exercise to lower blood sugar in adults with type 2 diabetes when treatment with both linagliptin and metformin is appropriate.

JENTADUETO and JENTADUETO XR are not for people with type 1 diabetes or for people with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had inflammation of the pancreas (pancreatitis) in the past, it is not known if you have a higher chance of getting pancreatitis while you take JENTADUETO or JENTADUETO XR.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about JENTADUETO or JENTADUETO XR?

JENTADUETO and JENTADUETO XR can cause serious side effects, including Lactic Acidosis (a build-up of lactic acid in the blood). Metformin, one of the medicines in JENTADUETO and JENTADUETO XR, can cause lactic acidosis, a rare but serious condition that can cause death. Lactic acidosis is a medical emergency and must be treated in a hospital.

Call your doctor right away if you get any of the following symptoms, which could be signs of lactic acidosis: feel cold in your hands or feet, feel dizzy or lightheaded, have a slow or irregular heartbeat, feel very weak or tired, have unusual muscle pain, have trouble breathing, feel sleepy or drowsy, have stomach pains, nausea, or vomiting.

You have a higher chance of getting lactic acidosis with JENTADUETO or JENTADUETO XR if you have severe kidney problems or your kidneys are affected by certain x-ray tests that use injectable dye, liver problems, drink alcohol very often, or drink a lot of alcohol in short term (“binge” drinking), get dehydrated (lose a large amount of body fluids), have surgery, have a heart attack, severe infection, or stroke.

Inflammation of the pancreas (pancreatitis) is another serious side effect that can happen to people taking JENTADUETO or JENTADUETO XR. Pancreatitis may be severe and lead to death. Before you start taking JENTADUETO or JENTADUETO XR tell your doctor if you have ever had pancreatitis, gallstones, a history of alcoholism, or high triglyceride levels.

Stop taking JENTADUETO or JENTADUETO XR and call your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis.

Heart failure. Heart failure means your heart does not pump blood well enough. Before you start taking JENTADUETO or JENTADUETO XR, tell your doctor if you have ever had heart failure or have problems with your kidneys. Contact your doctor right away if you have any of the following symptoms: increasing shortness of breath or trouble breathing, especially when you lie down; swelling or fluid retention, especially in the feet, ankles, or legs; an unusually fast increase in weight or unusual tiredness. These may be symptoms of heart failure.

Who should not take JENTADUETO or JENTADUETO XR?

Do not take JENTADUETO or JENTADUETO XR if you:

What should I tell my doctor before using JENTADUETO or JENTADUETO XR?

Tell your doctor about all of your medical conditions, including if you:

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. JENTADUETO or JENTADUETO XR may affect the way other medicines work, and other medicines may affect how JENTADUETO or JENTADUETO XR works.

Especially tell your doctor if you take:

*These trademarks are owned by third parties not affiliated with JENTADUETO or JENTADUETO XR.

What are the possible side effects of JENTADUETO and JENTADUETO XR?

JENTADUETO and JENTADUETO XR may cause serious side effects, including:

The most common side effects of JENTADUETO and JENTADUETO XR include stuffy or runny nose, sore throat, and diarrhea.

These are not all the possible side effects of JENTADUETO and JENTADUETO XR. For more information, ask your doctor or pharmacist.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑10881‑800‑FDA‑1088.

CL-JD-100001 8.21.17

Please see Prescribing Information, including Boxed Warning about lactic acidosis, and Medication Guide for JENTADUETO.
Please see Prescribing Information, including Boxed Warning about lactic acidosis, and Medication Guide for JENTADUETO XR.