FOR U.S. RESIDENTS ONLY AGE 18 AND OVER

ASK Your Doctor About Jentadueto

Blood sugar levels can be difficult to manage

Jentadueto may be able to help along with diet and exercise

Prescription JENTADUETO (linagliptin/metformin HCI), along with diet and exercise, may be able to help

Ask your doctor about Jentadueto

Ask your doctor if JENTADUETO is right for you

IS JENTADUETO RIGHT FOR YOU?

Your A1C test measures your average blood sugar control over 3 months. The results from your A1C test will show how well your blood sugar is currently controlled. If your A1C level continues to be too high, discuss setting a treatment goal with your doctor. JENTADUETO is an option that may be right for you if you need help lowering your A1C levels.

JENTADUETO works to regulate blood sugar by stimulating your pancreas to produce more insulin− especially after meals, when sugar levels rise. It also stimulates your liver to produce less glucose.

JENTADUETO is a prescription medicine that is used along with diet and exercise to help lower A1C levels in adults with type 2 diabetes. As with any treatment plan, you should discuss your options thoroughly with your doctor.

JENTADUETO is a prescription medicine that contains 2 diabetes medicines, linagliptin and metformin. JENTADUETO can be used along with diet and exercise to lower blood sugar in adults with type 2 diabetes when treatment with both linagliptin and metformin is appropriate.

JENTADUETO is not for people with type 1 diabetes.

If you have had inflammation of the pancreas (pancreatitis) in the past, it is not known if you have a higher chance of getting pancreatitis while you take JENTADUETO.

JENTADUETO is not for everyone:

Do not take JENTADUETO if you:
  • have severe kidney problems.
  • have a condition called metabolic acidosis or diabetic ketoacidosis (increased ketones in the blood or urine).
  • are allergic to linagliptin, metformin or any of the ingredients in JENTADUETO.

Symptoms of an allergic reaction may include rash, itching, flaking or peeling; raised red patches on your skin (hives); and swelling of your face, lips, tongue and throat that may cause difficulty breathing or swallowing. If you have any symptoms of a serious allergic reaction, stop taking JENTADUETO and call your doctor or go to the emergency room right away.

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Your Doctor Discussion Guide

You probably have a lot of questions about your treatment and how to move forward with your treatment plan. Your Doctor Discussion Guide will help you organize your questions for your next doctor's visit.

JENTADUETO is not for people with type 1 diabetes. If you have had inflammation of the pancreas (pancreatitis) in the past, it is not known if you have a higher chance of getting pancreatitis while you take JENTADUETO.


HOW OFTEN DO YOU...

Exercise?
Eat
healthy
foods?

WHAT IS YOUR
APPROXIMATE A1C?

A1C

Questions I'd Like To Ask

Select any of the following questions you would like to remember to ask your doctor

What is my A1C number and what should it be?
If my A1C number is getting higher, what can I do?
How would an additional medication help?
How does JENTADUETO work?
Can JENTADUETO help get my A1C headed in a different direction?
Is JENTADUETO right for me?
SELECT ALL QUESTIONS

What are JENTADUETO and JENTADUETO XR?

JENTADUETO and JENTADUETO XR are prescription medicines that contain 2 diabetes medicines, linagliptin (TRADJENTA) and metformin hydrochloride. JENTADUETO and JENTADUETO XR can be used along with diet and exercise to lower blood sugar in adults with type 2 diabetes.

JENTADUETO and JENTADUETO XR are not for people with type 1 diabetes. If you have had inflammation of the pancreas (pancreatitis) in the past, it is not known if you have a higher chance of getting pancreatitis while you take JENTADUETO or JENTADUETO XR.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about JENTADUETO or JENTADUETO XR?

JENTADUETO and JENTADUETO XR can cause serious side effects, including Lactic Acidosis (a build-up of lactic acid in the blood). Metformin, one of the medicines in JENTADUETO and JENTADUETO XR, can cause lactic acidosis, a rare but serious condition that can cause death. Lactic acidosis is a medical emergency and must be treated in a hospital.

Stop taking JENTADUETO or JENTADUETO XR and call your healthcare provider right away or go to the nearest hospital emergency room if you get any of the following symptoms, which could be signs of lactic acidosis: feel very weak and tired, have unusual muscle pain, have trouble breathing, have stomach or intestinal problems with nausea and vomiting, or diarrhea, feel sleepy or sleep longer than usual, feel cold in your arms and legs, feel dizzy or lightheaded, or have a slow or irregular heartbeat.

You have a higher chance of getting lactic acidosis with JENTADUETO or JENTADUETO XR if you have severe kidney problems, liver problems, drink a lot of alcohol (very often or short-term "binge" drinking), get dehydrated (lose a large amount of body fluids), have x-ray tests with injectable dye, have surgery, have congestive heart failure, have a heart attack, severe infection, or stroke, or are 65 years of age or older.

Inflammation of the pancreas (pancreatitis) is another serious side effect that can happen to people taking JENTADUETO or JENTADUETO XR. Pancreatitis may be severe and lead to death. Before you start taking JENTADUETO or JENTADUETO XR tell your healthcare provider if you have ever had pancreatitis, gallstones, a history of alcoholism, or high triglyceride levels.

Stop taking JENTADUETO or JENTADUETO XR and call your healthcare provider right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis.

Who should not take JENTADUETO or JENTADUETO XR?

Do not take JENTADUETO or JENTADUETO XR if you:

What should I tell my healthcare provider before using JENTADUETO or JENTADUETO XR?

Tell your healthcare provider about all of your medical conditions, including if you:

Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. JENTADUETO or JENTADUETO XR may affect the way other medicines work, and other medicines may affect how JENTADUETO or JENTADUETO XR works.

Especially tell your healthcare provider if you take:

What are the possible side effects of JENTADUETO and JENTADUETO XR?

JENTADUETO and JENTADUETO XR may cause serious side effects, including:

The most common side effects of JENTADUETO and JENTADUETO XR include stuffy or runny nose, sore throat, and diarrhea.

These are not all the possible side effects of JENTADUETO and JENTADUETO XR. For more information, ask your healthcare provider or pharmacist.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑10881‑800‑FDA‑1088.

CL-JD-100033 4.22.2022

Please see Prescribing Information, including Boxed Warning about lactic acidosis, and Medication Guide for JENTADUETO.
Please see Prescribing Information, including Boxed Warning about lactic acidosis, and Medication Guide for JENTADUETO XR.

What are JENTADUETO and JENTADUETO XR?

JENTADUETO and JENTADUETO XR are prescription medicines that contain 2 diabetes medicines, linagliptin (TRADJENTA) and metformin hydrochloride. JENTADUETO and JENTADUETO XR can be used along with diet and exercise to lower blood sugar in adults with type 2 diabetes.

JENTADUETO and JENTADUETO XR are not for people with type 1 diabetes. If you have had inflammation of the pancreas (pancreatitis) in the past, it is not known if you have a higher chance of getting pancreatitis while you take JENTADUETO or JENTADUETO XR.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about JENTADUETO or JENTADUETO XR?

JENTADUETO and JENTADUETO XR can cause serious side effects, including Lactic Acidosis (a build-up of lactic acid in the blood). Metformin, one of the medicines in JENTADUETO and JENTADUETO XR, can cause lactic acidosis, a rare but serious condition that can cause death. Lactic acidosis is a medical emergency and must be treated in a hospital.

Stop taking JENTADUETO or JENTADUETO XR and call your healthcare provider right away or go to the nearest hospital emergency room if you get any of the following symptoms, which could be signs of lactic acidosis: feel very weak and tired, have unusual muscle pain, have trouble breathing, have stomach or intestinal problems with nausea and vomiting, or diarrhea, feel sleepy or sleep longer than usual, feel cold in your arms and legs, feel dizzy or lightheaded, or have a slow or irregular heartbeat.

You have a higher chance of getting lactic acidosis with JENTADUETO or JENTADUETO XR if you have severe kidney problems, liver problems, drink a lot of alcohol (very often or short-term "binge" drinking), get dehydrated (lose a large amount of body fluids), have x-ray tests with injectable dye, have surgery, have congestive heart failure, have a heart attack, severe infection, or stroke, or are 65 years of age or older.

Inflammation of the pancreas (pancreatitis) is another serious side effect that can happen to people taking JENTADUETO or JENTADUETO XR. Pancreatitis may be severe and lead to death. Before you start taking JENTADUETO or JENTADUETO XR tell your healthcare provider if you have ever had pancreatitis, gallstones, a history of alcoholism, or high triglyceride levels.

Stop taking JENTADUETO or JENTADUETO XR and call your healthcare provider right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis.

Who should not take JENTADUETO or JENTADUETO XR?

Do not take JENTADUETO or JENTADUETO XR if you:

What should I tell my healthcare provider before using JENTADUETO or JENTADUETO XR?

Tell your healthcare provider about all of your medical conditions, including if you:

Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. JENTADUETO or JENTADUETO XR may affect the way other medicines work, and other medicines may affect how JENTADUETO or JENTADUETO XR works.

Especially tell your healthcare provider if you take:

What are the possible side effects of JENTADUETO and JENTADUETO XR?

JENTADUETO and JENTADUETO XR may cause serious side effects, including:

The most common side effects of JENTADUETO and JENTADUETO XR include stuffy or runny nose, sore throat, and diarrhea.

These are not all the possible side effects of JENTADUETO and JENTADUETO XR. For more information, ask your healthcare provider or pharmacist.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑10881‑800‑FDA‑1088.

CL-JD-100033 4.22.2022

Please see Prescribing Information, including Boxed Warning about lactic acidosis, and Medication Guide for JENTADUETO.
Please see Prescribing Information, including Boxed Warning about lactic acidosis, and Medication Guide for JENTADUETO XR.